West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 19 8 2018 08 01 Main Risk Factors Association with Proto-Oncogene Mutations in Colorectal Cancer 2183 2190 66140 10.22034/APJCP.2018.19.8.2183 EN Roya Dolatkhah Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. 0000-0002-6611-9958 Mohammad Hossein Somi Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. 0000-0002-6611-9958 Reza Shabanloei Department of Medical- Surgical Nursing, Nursing and Midwifery Faculty, Tabriz University of Medical Sciences, Tabriz, Iran. Faris Farassati The University of Kansas Medical School-Molecular Medicine Laboratory, Kansas City, KS, USA. Ali Fakhari Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Saeed Dastgiri Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Tabriz Health Services Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Journal Article 2018 01 12 Objective: Although several factors have been shown to have etiological roles in colorectal cancer, few investigations<br />have addressed how and to what extent these factors affect the genetics and pathology of the disease. Precise relationships<br />with specific genetic mutations that could alter signaling pathways involved in colorectal cancer remain unknown.<br />We therefore aimed to investigate possible links between lifestyle, dietary habits, and socioeconomic factors and specific<br />mutations that are common in colorectal cancers. Methods: Data were retrieved from a baseline survey of lifestyle factors,<br />dietary behavior, and SES, as well as anthropometric evaluations during a physical examination, for 100 confirmed<br />primary sporadic colorectal cancer patients from Northwest Iran. Results: High socioeconomic status was significantly<br />associated with higher likelihood of a KRAS gene mutation (P < 0.05) (odds ratio: 3.01; 95% CI: 0.69–13.02). Consuming<br />carbohydrates and alcohol, working less, and having a sedentary lifestyle also increased the odds of having a KRAS<br />mutation. Conclusion: Although research has not yet described the exact relationships among genetic mutations with<br />different known risk factors in colorectal cancer, examples of the latter may have an impact on KRAS gene mutations. https://journal.waocp.org/article_66140_7cffbe6b6734f7ac9e592845b729f0a4.pdf