West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 19 9 2018 09 01 Nutrient Patterns and Risk of Breast Cancer among Iranian Women: a Case- Control Study 2619 2624 66556 10.22034/APJCP.2018.19.9.2619 EN Samira Sadat Fereidani Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Hasan Eini-Zinab Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Zeinab Heidari Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Saba Jalali Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Fatemeh Sedaghat Department of Basic Medical Sciences, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Bahram Rashidkhani Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Journal Article 2018 04 30 Objective: To explore the role of nutrient patterns in the etiology of breast cancer (BCa) among Iranian women.<br />Methods: The study included 134 newly diagnosed cases of BCa and 267 hospitalized controls. A validated<br />semi-quantitative food frequency questionnaire (FFQ) was used to assess dietary intake. Nutrient patterns were obtained<br />using principal component analysis using Varimax rotation and logistic regression was performed to estimate breast<br />cancer risk. Results: We identified 4 major nutrient patterns. First was high in consumption of vitamins B1, B2, B3, B5,<br />B6, B9, C, magnesium, iron, carbohydrate, fiber, selenium, zinc, protein, potassium, and calcium. The second nutrient<br />pattern included Vitamins B12, A and cholesterol, while the third featured vitamin D, EPA and DHA. The fourth was<br />characterized by vitamin E, MUFA and saturated fatty acids. After adjusting for age, patterns 1 and 3 were associated<br />with a lower risk of BCa (OR=0.51, 95% CI: 0.33- 0.80, P=0.003, OR=0.64, 95% CI: 0.42- 0.98, P= 0.04 respectively).<br />However, after further adjustment for all confounders in multivariate analysis, the association remained significant only<br />for pattern 1 (OR=0.52, 95% CI: 0.32- 0.82, P=0.006). Conclusion: Adherence to a nutrient pattern rich in vitamin B,<br />minerals and fiber is associated with a lower risk of breast cancer. https://journal.waocp.org/article_66556_d546ba1951665e1f1150c34861856eea.pdf