West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 19 12 2018 12 01 Association of IL-10 rs1800871 and rs1800872 Polymorphisms with Breast Cancer Risk: A Systematic Review and Meta-Analysis 3353 3359 77417 10.31557/APJCP.2018.19.12.3353 EN Mansour Moghimi Department of Pathology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Hossein Ahrar Department of Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Mojgan Karimi-Zarchi Department of Gynecology and Obstetrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Kazem Aghili Department of Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Marjansadat Salari Department of Biology, Ashkezar Branch, Islamic Azad University, Yazd, Iran. Masoud Zare-Shehneh Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Hossein Neamatzadeh Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Journal Article 2018 09 15 Background: The rs1800871 and rs1800872 polymorphisms of interleukin 10 (IL-10) gene has been indicated to<br />be associated with breast cancer (BC) risk, but study results are still debatable. To derive a more precise evaluation, we<br />performed a comprehensive meta-analysis. Methods: Multiple electronic databases were searched to identify studies<br />assessing the IL-10 rs1800871 and rs1800872 polymorphisms with BC risk. Results: A total of 21 case-control studies<br />with 6054 cases and 6355 controls were included in this met-analysis. There was a significant association between the<br />rs1800871 polymorphism and BC risk (CT vs. TT: OR= 1.17, 95% CI 1.01-1.35, p=0.02; and CC+CT vs. TT: OR= 1.29,<br />95% CI 1.00-1.66, p=0.04). Moreover, increased BC risks were also associated with the rs1800872 polymorphism (C<br />vs. A: OR= 1.29, 95% CI 1.04-1.60, p=0.01; CC vs. AA: OR= 1.54, 95% CI 1.03-2.30, p=0.03; CC+CA vs. AA: OR=<br />1.43, 95% CI 1.01-2.01, p=0.03; and CC vs. CA+AA: OR= 1.23, 95% CI 1.01-1.51, p=0.04). A pooling of the studies<br />was also conducted by ethnicity, but failed to show an association of IL-10 rs1800871 and rs1800872 polymorphism<br />with BC risk in Asians and Caucasians. Conclusions: Our results are inconsistent with previous meta-analysis suggests<br />that IL-10 rs1800871 and rs1800872 polymorphisms might contribute to BC susceptibility in overall population, but<br />not by ethnicity. https://journal.waocp.org/article_77417_52a43dd5a140e41f1052c6e419b48ddf.pdf