West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 20 1 2019 01 01 Survival Rate of Colorectal Cancer in Iran: A Systematic Review and Meta-Analysis 13 21 81665 10.31557/APJCP.2019.20.1.13 EN Khadije Maajani Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences Tehran, Iran. Mahmoud Khodadost Gerash University of Medical Sciences, Gerash, Iran. Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. Arash Fattahi Department of Neurosurgery, Iran University of Medical Sciences, Tehran, Iran. Ehsan Shahrestanaki Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences Tehran, Iran. Aliyar Pirouzi Gerash University of Medical Sciences, Gerash, Iran. Fateme Khalili Vice-Chancellery for health, Isfahan University of Medical Sciences, Isfahan, Iran. Hamed Fattahi Health Management and Economics Research Center, Iran University of Medical Sciences, Tehran, Iran. Journal Article 2018 01 10 Background: Different studies have been conducted to estimate the survival rate of colorectal cancer in Iran but<br />there is no overall estimate of the survival rate. The aim of this study was to calculate the pooled 1, 3, and 5-year survival<br />rate of the patients with colorectal cancer in Iran. Methods: To retrieve relevant studies, we conducted a systematic<br />search in Iranian databases, including Iran Medex, Magiran, SID, and international databases such as Medlin/PubMed,<br />Scopus, and Google scholar using “Colorectal Neoplasms” and “Survival Rate” as keywords up to December 1st, 2017.<br />We used random effect model to estimate pooled 1, 3, and 5-year survival rates of the patients with colorectal cancer<br />in Iran. To assess the heterogeneity, we used Chi-squared test at the 5 % significance level (p <0.05) and I2 Index. We<br />used meta-regression and subgroup analysis to find a potential source of heterogeneity. Results: After a systematic<br />search, 196 articles were found, of the 38 studies met the eligibility criteria and are included in our meta-analysis. The<br />pooled 1, 3, and 5-year survival rates in patient with colorectal cancer were 0.84 (95% CI: 0.81-0.87), 0.64 (95%CI:<br />0.59-0.70), and 0.54 (95%CI: 0.49-0.58) respectively. The 5-year survival rate in the subgroup of women was 0.5<br />(0.44-0.56) and in male subgroup was 0.44 (0.40-0.48). In a subgroup of the tumor site, the 5-year survival rate in colon<br />cancer was 0.6 (0.49-0.75) and rectum cancer was 0.54 (0.36-0.69). In multivariable models, there was a significant<br />association between years of study and 5-year survival rate as a source of heterogeneity (β = 18.9, P=0.01). Conclusion:<br />According to the results of this study, women had a better survival rate than men, and according to the tumor site, the<br />5-year survival rate in colon cancer was better than the rectum cancer. https://journal.waocp.org/article_81665_7169b22b93325ab4b3466631dbef364a.pdf