West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 20 2 2019 02 01 Hyperthermic Intraperitoneal Chemotherapy Versus Systemic Chemotherapy in Recurrent Platinum-Sensitive Ovarian Cancer NCI Case Control Study 621 627 82398 10.31557/APJCP.2019.20.2.621 EN Gamal Amira Department of Surgical Oncology, National Cancer Institute, Cairo University, Egypt. Ahmed Morsi Department of Surgical Oncology, National Cancer Institute, Cairo University, Egypt. Ihab Samy Fayek Department of Surgical Oncology, National Cancer Institute, Cairo University, Egypt. Osman Mansour Department of Medical Oncology, National Cancer Institute, Cairo University, Egypt. Heba Nader Department of Surgical Oncology, National Cancer Institute, Cairo University, Egypt. Journal Article 2018 09 27 Objectives: To assess the efficacy of cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal<br />chemotherapy (HIPEC) in recurrent platinum-sensitive ovarian cancer patients in comparison with standard intravenous<br />chemotherapy in terms of progression free survival and overall survival. Methods: Retrospective case control study<br />matching 15 cases with 20 controls with at least 24 months of follow up. Results: The two groups were comparable<br />and well matched in all aspects. Median follow up was 36 months in cases and 38 months in controls. The PFS2<br />revealed a median of 6 months (range 2-14) in cases and 5 months (range 2-18) in controls. The median OS was 36<br />and 38 months in cases and controls respectively. No statistically significant difference between the cases and controls<br />were observed in progression free survival (PFS2) and overall survival OS (P-value, 0.350 and 0.711 respectively).<br />However, the PFS2 was in favor of cases and OS was in favor of controls without reaching significance. The percentage<br />of patients who survived 5 years or more was 20% in cases and 35% in controls. The only issue in favor of HIPEC<br />is the significant reduction in chemotherapeutic toxicity when given by the intraperitoneal way (P- value 0.003).<br />Conclusion: According to our study, CRS and HIPEC do not seem to have impact on OS and PFS in the setting of<br />recurrent platinum sensitive ovarian cancer. However, we recommend on going researches with much more refined<br />selection criteria and with larger sample size. https://journal.waocp.org/article_82398_e38f0145c84ba02b891bc1f31e1a2831.pdf