West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 20 2 2019 02 01 Alteration of the Risk of Oral Pre-cancer and Cancer in North India Population by CYP1A1 Polymorphism Genotypes and Haplotype 345 354 82552 10.31557/APJCP.2019.20.2.345 EN Kumud Nigam Department of Oral Pathology and Microbiology, King George’s Medical University, Lucknow, India. Somali Sanyal Amity Institute of Biotechnology, Amity University, Lucknow, India. Shalini Gupta Department of Oral Pathology and Microbiology, King George’s Medical University, Lucknow, India. Om Prakash Gupta Department of Surgery, SHM Medical College, Saharanpur, U.P. Abbas Ali Mahdi Department of Biochemistry, King George’s Medical University, Lucknow, India. M L B Bhatt Department of Radiotherapy, King George’s Medical University, Lucknow, India. Journal Article 2017 07 19 Background: The aim of this study was to evaluate any association between CYP1A1 (T6235C and C4887A,<br />A4889G) gene polymorphisms and the risk of oral pre-cancer and cancer. Methods: In the present study, 250 patients<br />with oral pre-cancer and/or cancer and 250 healthy controls were genotyped for CYP1A1 T6235C, C4887Aand A4889G<br />polymorphisms by the PCR-RFLP method. Results: None of the CYP1A1 polymorphisms were associated with the risk of<br />either oral cancer or pre cancer. Nor were any links with clinical parameters of oral cancer found. However, among the<br />consumers of areca nut/pan masala the TC, CA and AG genotypes respectively for the CYP1A1 T6235C,C4887Aand<br />A4889G polymorphisms were significantly more frequent in controls compared to cases ( p values for cases vs. controls<br />of 0.0032, 0.0019 and 0.0009, respectively). Similarly, compared to the haplotype TCA, TAG constituted by CYP1A1<br />T6235C and C4887A and A4889G was more common in controls (6.88%) than in cases (4.07%). Conclusion: Our<br />results suggest that genotypes regarding CYP1A1 polymorphisms may modulate the risk of oral cancer and pre-cancer<br />among the areca nut/pan masala consumers. The haplotype may also exert an influence in our north Indian population. https://journal.waocp.org/article_82552_4799f7bcc958a3c1faa5bb39b2f95eae.pdf