West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 20 3 2019 03 01 The Role of Muscle Relaxants – Spasmolytic (Thiocochlicoside) in Postoperative Pain Management after Mastectomy and Breast Reconstruction 743 749 82577 10.31557/APJCP.2019.20.3.743 EN Maria Bourazani Department of Anesthesiology, Hellenic Anticancer Institute, Saint Savvas Hospital, Greece. 0000-0003-3921-6581 Effie Papageorgiou Department of Medical Laboratories, University of West Attikis, Greece. Georgios Zarkadas Department of Plastic Surgery, Saint Savvas Hospital, Greece. Theodora Petrakopoulou Department of Plastic Surgery, Saint Savvas Hospital, Greece. Evridiki Kaba Department of Nursing, University of West Attikis, Greece. Georgia Fasoi Department of Nursing, University of West Attikis, Greece. Martha Kelesi Department of Nursing, Technological Educational Institute of Athens, Athens, Greece. Journal Article 2018 05 22 Purpose: Post-operative pain after breast cancer surgery is a major problem and women undergoing mastectomy<br />and breast reconstruction experience post-operative pain syndromes in approximately one-half of all cases. Patients<br />who have undergone breast reconstruction after mastectomy can suffer from acute postoperative pain with moderate<br />or strong tension. In some cases, chronic neuropathic pain syndromes may occur after surgery. Opioids are used to<br />treat pain, with serious side effects. The systemic postoperative analgesic regimen as thiocochlicoside P.O. along<br />with paracetamol and NSAIDs I.V., which may limit the administration of opioids without reducing pain relief,<br />seems to be necessary. Materials and Methods: This study was a clinical trial randomizing 70 patients undergoing<br />breast reconstruction. Two main protocols of systematic post-operative analgesia, one using thiocochlicoside (group<br />A) and the other without them (group B), were used. Both groups received paracetamol X3 and lornoxicam X2 I.V.<br />systematically. The pain measurement scale (NPS) used to measure post-operative pain. Likert scales were used to<br />evaluate patient’s satisfaction and the difficulty from the side effects . An anonymous questionnaire was used for the<br />data collection. Results: Statistically significant difference was found between pain on the day of surgery (p = 0.017)<br />as well as the three subsequent days (p = 0.000). In group A , pain was reduced directly to half (Χ2 surgery pain =<br />93.888, p = 0.000) especially on the first post-operative day. In group A the satisfaction with analgesic treatment was<br />higher than in group B (p = 0.002). Conclusion: The use of thiocochlicoside in post-operative analgesia in breast<br />reconstruction after mastectomy contributes to reduce the pain intensity experienced by patients and to reduce the side<br />effects of opioid analgesics as a result of reduced demand for opioid analgesics. Patients who received the analgesia<br />using muscle relaxants-spasmolytic reported greater satisfaction. https://journal.waocp.org/article_82577_7f705934202af0b816b567fe58a76536.pdf