West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 20 4 2019 04 01 HPV Types Distribution in General Female Population and in Women Diagnosed with Cervical Cancer Across Western Kazakhstan 1089 1096 85923 10.31557/APJCP.2019.20.4.1089 EN Saule K Balmagambetova West Kazakhstan Marat Ospanov State Medical University, 68, Maresyev Street, Aktobe, Kazakhstan. 0000-0003-4080-5383 Andrea Tinelli Department of Obstetrics and Gynecology, Division of Experimental Endoscopic Surgery, Imaging, Technology and Minimally Invasive Therapy, Vito Fazzi Hospital, Lecce, Italy Olzhas N Urazayev West Kazakhstan Marat Ospanov State Medical University, 68, Maresyev Street, Aktobe, Kazakhstan. Kanshaiym Z Sakieva West Kazakhstan Marat Ospanov State Medical University, 68, Maresyev Street, Aktobe, Kazakhstan. Arip K Koyshybaev West Kazakhstan Marat Ospanov State Medical University, 68, Maresyev Street, Aktobe, Kazakhstan. 0000-0002-6164-8009 Dinara A Zholmukhamedova West Kazakhstan Marat Ospanov State Medical University, 68, Maresyev Street, Aktobe, Kazakhstan. Saltanat T Urazayeva West Kazakhstan Marat Ospanov State Medical University, 68, Maresyev Street, Aktobe, Kazakhstan. Journal Article 2018 07 18 Objective: to detect the HPV types distribution both in general female population and in women with first diagnosed<br />cervical cancer, including viral load in both groups. Methods: Qualitative detection and quantification of HPV was<br />performed by PCR-Real time method based on the Russian equipment and test systems (“DNA-Technology” LLC,<br />Russia). The DNA of low-risk (HPV 6, 11, 44) and possibly / potentially / high carcinogenic risk (HPV 16, 18, 26, 31,<br />33 , 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, 82), a total of 21 types, were detected. Results: During the period<br />of 2014-2017 total 1,166 clinically healthy women were tested for HPV, as well as 73 women diagnosed with CaCx.<br />Overall prevalence of HPV in female population was determined as 25.0% (95% CI 22.3;27.7, p = 0.05). Top-5 leading<br />HPV types: 16 (26.4%); 31 (10.1%); 51 (9.4%); 52 (9.0%); 6 (7.9%). Average viral load was 5.5±3.8 (CI 95% 5.1;5.9).<br />In women diagnosed with CaCx ranking was as follows – 16 (54.1%), 31 (11.2%), 18 / 58 (5.1% each), 33 / 45 (4.1%<br />each). Type 16 appeared to be one of the most significant risk factors of the CaCx development (p=0.00007, phi 0.35,<br />Pierson’s X 2 15.9). Average viral load in patients with CaCx was 6.9±4.0 (95% CI 6.1;7.7). A reliable relationship<br />between the cancer staging and the viral load was found (p = 0.043, n = 73). Domination of type 16 calls for urgent<br />need the transition to HPV primary screening and resumption of immunization program discontinued in 2014. The<br />study is registered in ISRCTN registry, No. ISRCTN71514910 (01.02.2018). https://journal.waocp.org/article_85923_35ab5b894ffa7602826762a2b9563700.pdf