West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 20 4 2019 04 01 XRCC4 c.1394G>T Single Nucleotide Polymorphisms and Breast Cancer Risk among Filipinos 1097 1101 86819 10.31557/APJCP.2019.20.4.1097 EN Julius Adrie Garcia The Graduate School, University of Santo Tomas, Manila, Philippines. Research Center for the Natural and Applied Sciences, University of Santo Tomas, Manila, Philippines. Noel Angelo Kalacas The Graduate School, University of Santo Tomas, Manila, Philippines. Research Center for the Natural and Applied Sciences, University of Santo Tomas, Manila, Philippines. 0000-0002-3507-7724 Teresa Sy Ortin The Graduate School, University of Santo Tomas, Manila, Philippines. University of Santo Tomas Hospital, Benavides Cancer Institute, Manila, Philippines. Maria Cristina Ramos The Graduate School, University of Santo Tomas, Manila, Philippines. Research Center for the Natural and Applied Sciences, University of Santo Tomas, Manila, Philippines. College of Science, University of Santo Tomas, Manila, Philippines. Pia Marie Albano The Graduate School, University of Santo Tomas, Manila, Philippines. Research Center for the Natural and Applied Sciences, University of Santo Tomas, Manila, Philippines. College of Science, University of Santo Tomas, Manila, Philippines. Journal Article 2018 08 03 Background: The identification of cancer-associated single nucleotide polymorphisms (SNP) and mutation<br />genes is a promising approach in recognizing individuals who are at risk of developing cancer. Hence, this study<br />was conducted to determine the association between XRCC4 c.1394G>T SNP and breast cancer development among<br />Filipinos. Methods: Genotyping for XRCC4 c.1394G>T SNP was performed on breast cancer patients (n=103) and<br />their age- and sex- matched clinically healthy controls (n=103) by polymerase chain reaction – restriction fragment<br />length polymorphism. Results: Significant difference in genotype (p=0.007) and allele (p=0.003) frequencies in XRCC4<br />c.1394G>T was observed between the breast cancer cases and controls. Carriers of the XRCC4 c.1394 G>T genotype<br />were observed to have significantly higher risk of developing breast cancer compared to individuals with T/T genotype<br />(OR=2.67, 95% CI: 1.36 – 5.25). XRCC4 c.1394G>T combined with passive smoking may also significantly increase<br />risk of breast cancer (OR=14.73; 95% CI= 9.88-18.86). Conclusion: XRCC4 c. 1394G>T may be associated with<br />breast cancer development among Filipinos. https://journal.waocp.org/article_86819_2a0d2ddbad16baf543e8543e273d2c1c.pdf