West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 20 7 2019 07 01 Association of Promoter Region Polymorphisms of IL-10 Gene with Susceptibility to Lung Cancer: Systematic Review and Meta-Analysis 1951 1957 88633 10.31557/APJCP.2019.20.7.1951 EN Jamal Jafari-Nedooshan Department of Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Mansour Moghimi Department of Pathology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Mohammad Zare Department of Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Naeimeh Heiranizadeh Department of Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Majid Morovati-Sharifabad Department of Basic Science, Faculty of Veterinary Medicine, Ardakan University, Ardakan, Iran. Mohamad Javad Akbarian-Bafghi Bam University of Medical Sciences, Department of Healthcare Management, Bam, Iran. Mohammad Hossein Jarahzadeh Department of Emergency Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Hossein Neamatzadeh Mother and New Born Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Journal Article 2018 09 22 Objective: Epidemiological studies have suggested that the promoter region polymorphisms of interleukin-10 (IL-10)<br />gene may be associated with an increased risk of lung cancer. However, those studies results are controversial. Thus, a<br />comprehensive meta-analysis was performed to evaluate the association of promoter region polymorphisms of IL-10<br />gene with susceptibility to lung cancer. Methods: a comprehensive search of PubMed, EMBASE, and CNKI databases<br />was performed to find all eligible studies up to September 15, 2018. The pooled odds ratios (ORs) with 95% confidence<br />intervals (CIs) were used to assess the strength of such association. Results: A total number of 19 case-control studies with<br />4084 cases and 6,131 controls were selected. The overall meta-analysis results showed that the -592A>C polymorphism<br />was significantly associated with lung cancer risk under four genetic models, i.e., allele (CT vs. TT: OR= 1.17, 95% CI<br />1.01-1.35, p=0.02), homozygote (CC vs. AA: OR= 1.64, 95% CI 1.29-2.02, p≤0.001), heterozygote (CA vs. AA: OR=<br />1.26, 95% CI 1.06-1.50, p≤0.001), and dominant (CC+CA vs. AA: OR= 1.31, 95% CI 1.11-1.54, p=0.001). However,<br />there was no significant association between -819T>C and -1082A>G polymorphisms of IL-10 and lung cancer risk.<br />Similarly, subgroup analyses by ethnicity detected significant association between IL-10 -592A>C and lung cancer<br />among Asians and Caucasians. Conclusions: Our meta-analysis suggests that the IL-10 -592A>C polymorphism might<br />be risk factor for lung cancer, especially among Asian and Caucasians. In contrast, the IL-10 -819T>C and -1082A>G<br />polymorphisms are not significantly associated with increased risk of lung cancer. https://journal.waocp.org/article_88633_195aff5c846c582ed3b33b47ad265251.pdf