West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 21 2 2020 02 01 Potency of Pfeiffer’s Crystallization to Analyze Oral Leukoplakia and Squamous Cell Carcinoma 517 522 88967 10.31557/APJCP.2020.21.2.517 EN Vanshika Makkar Oral and Maxillofacial Pathology and Oral Microbiology, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India. Mala Kamboj Oral and Maxillofacial Pathology and Oral Microbiology, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India. Anjali Narwal Oral and Maxillofacial Pathology and Oral Microbiology, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India. Rajeev Kumar Kapoor Department of Microbiology, Maharishi Dayanand University, Rohtak, Haryana, India. Journal Article 2019 10 14 Objective: Oral cancer usually has an early precancerous stage before its actual malignant transformation. Although there are various approaches to diagnose early stages of cancer, yet there is one less explored, cost effective and simple technique known as crystallization test. The aim of the study was to reaffirm the effectiveness of Pfeiffer’s crystallization test in screening oral leukoplakia and squamous cell carcinoma. Methods: Fifty oral leukoplakia, sixty five oral squamous cell carcinoma and sixty healthy individuals participated in crystallization test. Single blood drop was used to perform the test and obtained crystal patterns were analysed. Cross tabulation and Chi-Square test was performed to find the frequency and association between the groups. Kruskal-Wallis H test and Mann Whitney U test was applied comparing mean transverse form. Results: Sensitivity of crystallization test was 80% and 93.84% in oral leukoplakia and squamous cell carcinoma. Chi-Square analysis revealed highly significant transverse form between the study groups (p < 0.000). Conclusion: Crystallization test proves to be simple, reliable and minimal invasive diagnostic approach under strictly maintained physical conditions. https://journal.waocp.org/article_88967_355a1d3f543a3566e99bf01c6d58d8d1.pdf