West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 22 3 2021 03 01 Treatment Outcome and Prognosis Factors of FIGO 2018 Stage III Cervical Cancer Patients Treated with Definitive Concurrent Chemoradiation in Vietnam 853 859 89524 10.31557/APJCP.2021.22.3.853 EN Huyen Thi Phung Department of Medical Oncology 6, Vietnam National Cancer Hospital, Hanoi, Vietnam. Department of Oncology, Vietnam University of Traditional Medicine, Hanoi, Vietnam. Minh Cong Truong Department of Oncology, Hanoi Medical University, Hanoi, Vietnam. 0000-0003-3953-6729 Long Thanh Nguyen Department of Oncology, Hanoi Medical University, Hanoi, Vietnam. 0000-0002-0601-1013 Anh Thi Van Dang Department of Breast and Gynecologic Radiotherapy, Vietnam National Cancer Hospital, Hanoi, Vietnam. Thanh Ha Vu Department of Medical Oncology 2, Vietnam National Cancer Hospital, Hanoi, Vietnam. Hoa Thi Nguyen Department of Medical Oncology 6, Vietnam National Cancer Hospital, Hanoi, Vietnam. Journal Article 2020 11 17 Objective: This study aimed to analyze the treatment outcome and toxicities, along with prognosis factors of patients with FIGO 2018 stage III cervical cancer treated with definitive concurrent chemoradiation. Methods: A total of 83 stage III cervical cancer patients with good performance status (ECOG PS 0, 1) were treated with three-dimensional conformal radiation therapy (3D-CRT) combined with chemotherapy (weekly cisplatin), followed by high-dose-rate (HDR) brachytherapy between January 2017 and March 2019 at Vietnam National Cancer hospital. Treatment outcomes and prognosis factors were assessed along with acute and late toxicities. Results: The 3-year DFS was 67.8% and 3-year OS was 80.3%. On multivariate analyses, short axis of pelvic lymph node diameter of ≥ 15mm, invasion of the lower third of vagina and para-aortic lymph node metastasis were identified as adverse prognostic factors for DFS. The cumulative incidence rate of gastrointestinal and genitourinary toxicity (≥ grade 2) at the 3-year follow-up were 29.6% and 11.6%, respectively. Conclusions: 3D CRT and HDR brachytherapy with concurrent chemotherapy is an effective treatment, with acceptable toxicity for FIGO 2018 stage III cervical cancer in Vietnam.<br />   Cervical cancer 3D CRT 3-year DFS stage III late toxicity https://journal.waocp.org/article_89524_2815dc2f85860bbf2546534e8667d033.pdf