West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 22 10 2021 10 01 Association between Early Menopause, Gynecological Cancer, and Tobacco Smoking: A Cross-Sectional Study 3165 3170 89794 10.31557/APJCP.2021.22.10.3165 EN Joyce Mary Kim Department of Public Health, The Graduate School of Yonsei University, Seoul, Korea. Institute for Health Promotion, Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea. Yeun Soo Yang Department of Public Health, The Graduate School of Yonsei University, Seoul, Korea. Institute for Health Promotion, Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea. Su Hyun Lee Department of Public Health, The Graduate School of Yonsei University, Seoul, Korea. Institute for Health Promotion, Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea. Sun Ha Jee Department of Public Health, The Graduate School of Yonsei University, Seoul, Korea. 0000-0001-9519-3068 Journal Article 2021 03 28 Background: The rates of smoking among women are rising. Previous studies have shown that smoking is associated with early menopause. However, the association of gynecological cancer, including breast and cervical cancer, with early menopause and smoking, remains unclear. Therefore, this study aimed to determine the association between smoking and early menopause, breast cancer, and cervical cancer. Methods: This cross-sectional study used data from the Korean National Health and Nutritional Survey Examination (KHANES) (2016–2018). Early menopause was defined as menopause before 50 years of age. Results: A total of 4,481 participants were included in the analysis. There was no association between early menopause and cervical cancer (adjusted odds ratio [aOR]: 1.435, 95% confidence interval [CI]: 0.730–2.821), but women who had experienced early menopause had a significantly higher risk of breast cancer than women who had experienced normal menopause (aOR: 1.683, 95% CI: 1.089–2.602, p=0.019). Early menopause was not associated with an increased risk of breast cancer in ever-smoker (aOR: 0.475, 95% CI: 0.039–5.748), but was associated with a significantly increased risk of breast cancer in never-smokers (aOR: 1.828, 95% CI: 1.171–2.852). Conclusions: Early menopause was associated with an increased risk of breast cancer in women who had never smoked, but not in women who had ever smoked. https://journal.waocp.org/article_89794_d0f1f888d16b9df77ff193f6adef2c55.pdf