West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 24 3 2023 03 01 Protective Effect of Adenosine Triphosphate against 5-Fluorouracil-Induced Oxidative Ovarian Damage in vivo 1007 1013 90524 10.31557/APJCP.2023.24.3.1007 EN Mehmet Ozer Department of Obstetrics and Gynecology, Izmir Tepecik Regional Training Research Hospital, Izmir, Turkey. Sefa Ince Department of Obstetrics and Gynecology, Regional Training Research Hospital, Erzurum, Turkey. Durdu Altuner Department of Pharmacology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey. Zeynep Suleyman Department of Pharmacology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey. Betul Cicek Department of Physiology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey. Mine Gulaboglu Department of Biochemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey. Behzad Mokhtare Department of Pathology, Faculty of Veterinary, Ataturk University, Erzurum, Turkey. Cebrail Gursul Department of Physiology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey. Halis Suleyman Department of Pharmacology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey. Journal Article 2022 10 25 Objective: The aim of our study was to analyze the effect of ATP on possible ovarian damage of 5-FU in rats. Methods: The animals were divided to three groups; healthy group (HG), 5-FU alone group (FUG) and ATP+5-FU administered group (AFU). The ATP 4 mg/kg was injected intraperitoneally (IP) into the AFU group. The same volume of saline (0.9% NaCl) as the solvent was administered intraperitoneally to the HG and FUG groups. One hour after administering ATP and solvent, 5-FU 100 mg/kg was injected intraperitoneally to the animals in the AFU and FUG groups. ATP was administered to the animals once a day for 10 days. On the 1st, 3rd and 5th days of 5-FU, one dose (total of 3 doses) was administered. On day 10, the animals were euthanasia with high-dose anaesthesia and ovarian tissues were removed. The removed ovaries were analyzed biochemically andhistopathological. Result: ATP significantly suppressed both the increase in MDA and IL-6 levels, and the decrease in tGSH, SOD and CAT levels. Treatment with ATP significantly suppressed the severe vacuolization and primordial follicle degeneration induced by 5-FU in our study. Conclusion: ATP was possible to be useful for the treatment of 5-FU-induced ovarian damage. https://journal.waocp.org/article_90524_3d63462dac20b6c60af61e664309e521.pdf