West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 25 2 2024 02 01 High Expression of PXMP4 in Hepatocellular Carcinoma Tissues 603 608 91022 10.31557/APJCP.2024.25.2.603 EN Ming Ming Zhao Faculty of Medicine, Lincoln University College, Malaysia. Zarina Awang Faculty of Medicine, Lincoln University College, Malaysia. Farra Aidah Binti Jumuddin Faculty of Medicine, Lincoln University College, Malaysia. 0000-0002-3817-7050 Journal Article 2023 10 03 Objective: To analyze the high expression of peroxisome membrane protein 4 (PXMP4) in hepatocellular carcinoma (HCC) and its clinical significance. Methods:The expression of PXMP4 mRNA in HCC tissues and corresponding adjacent tissues was detected by Q-PCR, and the expression of PXMP4 protein was detected by Western blot and immunohistochemistry. The correlation of PXMP4 protein expression with clinicopathological features and prognosis of HCC was analyzed. Results: The expression levels of PXMP4 mRNA and protein in HCC tissues were significantly higher than those in adjacent tissues (P < 0.05), and its high expression was significantly correlated with tumor differentiation, lymph node metastasis, depth of invasion and TNM stage (P < 0.05). Patients with high expression of PXMP4 had a poor prognosis (P < 0.05). Conclusion: The high expression of PXMP4 may promote the occurrence and development of HCC, and inhibition of PXMP4 may be one of the potential molecular targets for targeted therapy of HCC. https://journal.waocp.org/article_91022_fb8913473114cd2f7905be55437c515a.pdf