West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 25 8 2024 08 01 The Prognostic Role of Fibulin-2 and Ki-67 Index in Patients with Meningioma: A Study among Minangkabau Ethnicity 2735 2742 91261 10.31557/APJCP.2024.25.8.2735 EN Yessy Setiawati Department of Anatomical Pathology, RSUP dr M Djamil, Padang, West Sumatra 25171, Indonesia. Department of Anatomical Pathology, Faculty of Medicine, Andalas University, Padang, West Sumatra 25175, Indonesia. Tofrizal Alimuddin Department of Anatomical Pathology, RSUP dr M Djamil, Padang, West Sumatra 25171, Indonesia. Department of Anatomical Pathology, Faculty of Medicine, Andalas University, Padang, West Sumatra 25175, Indonesia. Henny Mulyani Department of Anatomical Pathology, Faculty of Medicine, Andalas University, Padang, West Sumatra 25175, Indonesia. Muthia Kamelia Department of Anatomical Pathology, Faculty of Medicine, Andalas University, Padang, West Sumatra 25175, Indonesia. Journal Article 2024 01 07 Objective: To analyze the association between fibulin-2 and Ki-67 index with histopathological grade and other clinicopathological factors in patients with meningioma among the Minangkabau ethnic group. Methods: This cross-sectional observational study uses 50 specimens comprising 25 low-risk meningioma cases and 25 high-risk meningioma cases obtained at three anatomical pathology laboratories in Padang, West Sumatra, Indonesia, between 2019 and 2022. All samples were stained using an immunohistochemistry procedure with Ki-67 and fibulin-2. The chi-square test was used to assess IBM SPSS statistics version 26 for Windows was used to assess the association of Ki-67 and fibulin-2 with the histopathological grade. The p-value of <0.05 was considered significant. Result: We found a significant association between Ki-67 (p = 0.013) or fibulin-2 (p = 0.001) expression with histopathological grade of meningioma. High histopathological grade has high expression of Ki-67 and fibulin-2, with Odds ratio (OR) of 13.500 (1.556–117.137) and 10.028 (2,738–36,722), respectively. Fibulin-2 expression was also associated with the age of patients (p = 0.020). The low age group (<50) has high expression of fibulin-2 (OR 0.196 (0.056–0.691).  Conclusion: Ki-67 and fibulin-2 were associated with the histopathological grade of meningioma, while fibulin-2 is also associated with age in the Minangkabau ethnic group. https://journal.waocp.org/article_91261_8f8882a8396726900256b03e91ea29b5.pdf