West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 26 9 2025 09 01 Serum Vitamin D Levels and Vitamin D Receptor Concentrations in Children with Acute Lymphoblastic Leukemia: A Cross-Sectional Study 3265 3270 91830 10.31557/APJCP.2025.26.9.3265 EN Nadirah Rasyid Ridha Department of Pediatrics, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. Dr Wahidin Sudirohusodo Hospital, Makassar, Indonesia. 0000-0002-9636-0953 Darwati Muhadi Dr Wahidin Sudirohusodo Hospital, Makassar, Indonesia. Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. Muhammad Farid Huzein Department of Pediatrics, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. Purnamasari Natsir Putri Department of Pediatrics, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. Bahrul Fikri Department of Pediatrics, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. Dr Wahidin Sudirohusodo Hospital, Makassar, Indonesia. 0000-0003-2852-2647 Ema Alasiry Department of Pediatrics, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. Dr Wahidin Sudirohusodo Hospital, Makassar, Indonesia. 0000-0001-6166-9902 Martira Maddeppungeng Department of Pediatrics, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. Dr Wahidin Sudirohusodo Hospital, Makassar, Indonesia. Journal Article 2025 01 23 Introduction: Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, characterized by the proliferation of immature lymphoid cells. Vitamin D and its receptor (VDR) play a critical role in immune regulation and cancer progression. This study investigated serum vitamin D levels and VDR concentrations in children with ALL and their relationship with clinical risk groups. Methods: This cross-sectional study involved 90 children categorized into standard risk (SR), high risk (HR), and control groups at Dr. Wahidin Sudirohusodo Hospital in Makassar, Indonesia. Serum vitamin D levels and soluble VDR concentrations were measured using ELISA. Vitamin D status was classified as deficient (<20ng/mL), insufficient (20–30ng/mL), or sufficient (>30ng/mL). Statistical analysis compared the groups and examined associations with SPPS version 26. Results: Vitamin D deficiency was prevalent in 82.2% of ALL patients. The SR and HR groups showed significantly lower levels than controls (P<0.001). Median vitamin D levels were 13.29ng/mL (SR), 13.94ng/mL (HR), and 19.61 ng/mL (control). Median VDR concentrations were highest in the SR group (0.600ng/mL), though differences across groups were not statistically significant (P=0.163). A positive correlation between serum vitamin D levels and VDR concentrations was identified (P=0.001, r=0.342). Conclusion: Vitamin D deficiency is highly prevalent in children with ALL, highlighting the need for regular vitamin D screening and supplementation. Further research is necessary to explore the therapeutic potential of vitamin D and VDR in leukemia treatment. https://journal.waocp.org/article_91830_960c76e17a6e6b6897ff1bf80ac6fa3e.pdf