West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 26 9 2025 09 01 The Effect of Resistance Training on Serum Levels of Lipid Profile and Liver Enzymes in Male Rat Undergoing Radiotherapy 3259 3264 91860 10.31557/APJCP.2025.26.9.3259 EN Mohamad Parastesh Department of Sports Physiology and Pathology, Arak University, Arak, Iran. Mohamad Reza Bayatiani Department of Radiotherapy and Medical Physics, Faculty of Para Medicine, Arak University of Medical Sciences and Khansari Hospital, Arak, Iran. Fatemeh Seif Department of Radiotherapy and Medical Physics, Faculty of Para Medicine, Arak University of Medical Sciences and Khansari Hospital, Arak, Iran. Zahra Yuosofvand Department of Sports Physiology and Pathology, Arak University, Arak, Iran. Narges Abili Department of Sports Physiology and Pathology, Arak University, Arak, Iran. Journal Article 2025 01 16 Background: This study investigated the effects of resistance training on lipid profiles and liver enzyme levels in male rats exposed to x-ray radiation. Methods: In this experimental study, 24 eight-week-old Sprague Dawley rats (200-250g) were randomly assigned into four groups: healthy control, irradiated control, healthy resistance training, and irradiated resistance training. Irradiation was induced at a dose of 4 Gy on the whole body. The resistance training protocol was performed for ten weeks. Finally, blood serum was used to assess AST, ALT, ALP and testosterone, and lipid profile. Data were analyzed using ANOVA and Tukey’s post hoc test using SPSS-16 software at a 0.05 level of significance. Results: The results showed that radiation significantly increased serum levels of AST (169.3±2.4 ‏vs 131.1±2.4, P=0.001), ALT (75.6±3.6 vs 65.1±3.1, P=0.002), and ALP (503.5±83.1 ‏vs 370.3±66.9, P=0.034) between radiation control and healthy control groups. Also, no significant difference was observed between serum levels of AST (P=1.000) ALT (P=0.942), and ALP (P=0.925) in radiation resistance training and the healthy control groups. In addition, a significant increase was observed between radiation control and radiation resistance training groups in lipid profiles (P≥0.05). Also, no significant difference was observed between serum levels of TG (P=0.212) LDL-C (P=0.931), and HDL-C (P=0.992) in radiation resistance training and the healthy control groups. Conclusions: Our findings suggest that resistance training may improve lipid profiles and liver enzyme levels in male rats exposed to x-ray radiation. https://journal.waocp.org/article_91860_fef114d7007940df126f765e1e1229b6.pdf