Association Between XPD Asp312Asn Polymorphism and Esophageal Cancer Susceptibility: A Meta-analysis

Objective: To investigate the association between xeroderma pigmentosum group D (XPD) Asp312Asnpolymorphism and esophageal cancer (EC) susceptibility by meta-analysis.
Methods: We searched PubMed up toApril 9th, 2012, to identify relevant papers, and 8 published case-control studies including 2165 EC patients and3141 healthy controls were yielded. Odds ratios (ORs) with relevant 95% confidence intervals (CIs) were appliedto assess the association between XPD Asp312Asn polymorphism and EC susceptibility with the ComprehensiveMeta-Analysis software, version 2.2.
Results: Overall, the meta-analysis results suggested the XPD Asp312Asnpolymorphism to be significantly associated with EC susceptibility [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.20,95%CI=1.05-1.36, p=0.01; and Asp/Asn vs. Asp/Asp: OR= 1.15, 95%CI =1.01-1.31, p=0.04]. In the subgroupanalysis by ethnicity and cancer type, significantly associations were found for Caucasian populations [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.26, 95%CI =1.08-1.47, p<0.001; Asp/Asn vs. Asp/Asp: OR=1.19, 95%CI =1.02-1.40, p=0.03] and esophageal squamous cell carcinoma [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.19, 95%CI=1.01-1.41, p=0.04]. There was no heterogeneity and no publication bias existed.
Conclusions: This meta-analysisshows that the XPD Asp312Asn polymorphism may be a risk factor for developing EC, especially for Caucasianpopulations and esophageal squamous cell carcinoma.