Association Between the XRCC3 T241M Polymorphism and Head and Neck Cancer Susceptibility: a Meta-analysis of Case-control Studies


Background: To evaluate the role of the X-ray repair cross complementing group 3 (XRCC3) T241Mpolymorphism in head and neck cancer susceptibility. Materials and
Methods: We performed a meta-analysis ofall available studies, which included 3,191 cases and 5,090 controls.
Results: Overall, a significant risk effect of theT241M polymorphism was not found under homologous contrast (MM vs TT: OR=1.293, 95% CI=0.926-1.805;TM vs TT: OR=1.148 95% CI=0.930-1.418) and recessive models (MM vs TT+TM): OR=1.170, 95% CI=0.905-1.512, but a significantly increased risk was observed under a dominant model (MM+TM vs TT): OR=1.243,95% CI=1.001-1.544. In stratified analyses, there were no significant associations for Asians or Caucasians.
Conclusion: Our meta-analysis suggested the XRCC3 241M allele (MM+TM) might act as a head and neckcancer risk factor among all subjects, and the effect of T241M polymorphism on head and neck susceptibilityshould be studied with a larger, stratified population.