Objective: To evaluate the association of a diagnosis of lung cancer and combined detection of serumcarcinoembryonic antigen (CEA), carbohydrateantigen 19-9 (CA19-9), neuron specific enolase (NSE) as well asthe cytokeratin 19 fragment (CYFRA21-1).
Methods: Serum CEA, CA19-9, NSE and CYFRA21-1 were assessedin 150 patients with lung cancer, 100 patients with benign lung disease and 100 normal control subjects, anddifferences of expression were compared in each group, and joint effects of these tumor markers in the diagnosisof lung cancer were analyzed.
Results: Serum CEA, CA19-9, NSE and CYFRA21-1 in patients with lung cancerwere significantly higher than those with benign lung disease and normal controls (p<0.01). It is suggested thatthese four tumor markers combined together could produce a positive detection rate of 90.2%, significantlyhigher than that of any single test.
Conclusion: Combination detection of CEA, CA19-9, NSE and CYFRA21-1could significantly improve the sensitivity and specificity in diagnosis of lung cancer, and could be important inearly detection.