Significance of Caveolin-1 Regulators in Pancreatic Cancer


Caveolin-1 is a scaffold protein on the cell membrane. As the main component of caveolae, caveolin-1 is involvedin many biological processes that include substance uptake and transmembrane signaling. Many of these processesand thus caveolin-1 contribute to cell transformation, tumorigenesis, and metastasis. Of particular interestare the dual rolesof tumor suppressor and oncogene that caveolin-1 appear to play in different malignancies,including pancreatic cancer. Therefore, analyzing caveolin-1 regulators and understanding their mechanisms ofactionis key to identifying novel diagnostic and therapeutic tools for pancreatic cancer. This review details themechanisms of action of caveolin-1 regulators and the potential significance for pancreatic cancer treatment.