Levels of Serum 25-Hydroxy-Vitamin D in Benign and Malignant Breast Masses


Background: The true association between breast cancer and vitamin D is currently under investigation.We compared serum 25-hydroxy-vitamin D levels in women with benign and malignant breast masses andcontrols. Materials and
Methods: Levels of vitamin D were measured by electrochemiluminescense. Serum levels>35 ng/ml, 25-35 ng/ml, 12.5-25 ng/ml and <12.5 ng/ml were considered as normal, mild, moderate and severevitamin D deficiency, respectively.
Results: Overall, 364 women were included in the control, 172 in the benignand 136 in the malignant groups. The median serum vitamin D level was significantly lower in breast cancersthan controls. Levels were also lower in malignant than benign cases and in benign cases than controls althoughstatistically non-significant.
Conclusions: Multinomial logistic regression analysis showed that severe vitamin Ddeficiency causes a three-fold increase in the risk of breast cancer while this was not the case for moderate andmild deficiency.