Cyclooxygenase-2 Promoter 765C Increase of Digestive Tract Cancer Risk in the Chinese Population: a Meta-analysis


Background: To evaluate relationship between the cyclooxygenase-2 promoter 765G/C polymorphism anddigestive cancer risk in China. Materials and
Methods: A literature search through February 2014 was performedusing PubMed, Chinese Biomedical Literature Database (CBM) and China National Knowledge Infrastructure(CNKI) databases, and a meta-analysis was performed with RevMan 5.2 software for odds ratios and 95%CIs.
Results: In total, 9 articles with 3,263 cases and 4,858 controls were included in this meta-analysis.The pooled OR(95%CIs) in the co-dominant model (GC vs GG) was 1.56 [1.19, 2.06], and in the dominant model ((CC+GC) vsGG), the pooled OR was 1.59 [1.21, 2.09] in overall cancers. In the subgroup analysis, stratified by cancer type,significant associations were found that the-765C allele had increased pancreatic cancer and gastric risk. Nosignificant liver cancer and colorectal cancer risk of COX-2 -765G/C polymorphism was found.
Conclusions: Thesefindings suggest that COX-2-765*C is related to cancer susceptibility and may increase gastric and pancreaticcancer risk.