Clinical, Histopathological and Molecular Characteristics of Metastatic Breast Cancer in North-Eastern Kazakhstan: a 10 Year Retrospective Study

Document Type : Research Articles


1 Semey State Medical University

2 Central EurAsian Institute for Cancer Research, Bishkek, Kyrgyzstan

3 Semey State Medical Universit

4 Kazakh Medical University, named after S.D Asfendiyarov


Background: Breast cancer (BC) is the top cancer among women worldwide and has been the most frequent
malignancy among Kazakhstan women over the past few decades. Information on clinical and histopathological
features of metastatic breast cancer (MBC), as well as the distribution of molecular subtypes is limited for Kazakh
people. Materials and Methods: The present observational retrospective study was carried out at Regional
Oncologic Dispensaries in the North-East Region of Kazakhstan (in Semey and Pavlodar cities). –°linical and
histopathological data were obtained for a total of 570 MBC patients in the 10 year period from 2004-2013, for
whom data on molecular subtype were available for 253. Data from hospital charts were entered into SPSS 20
for analysis by one-way ANOVA analysis of associations of different variables with 1-5 year survival. Pearson
correlation and linear regression models were used to examine the relation between parameters with a p-value
< 0.05 considered statistically significant. Results: No significant relationships were evident between molecular
subtype and survival, site of metastases, stage or ethnicity. Young females below the age of 44 were slightly more
likely to have triple negative lesions. While the ductal type greatly predomonated, luminal A and B cases had a
higher percentage with lobular morphology. Conclusions: In this select group of metastatice brease cancer, no
links were noted for survival with molecular subtype, in contrast to much of the literature.