Impact of Cyclin D1 and Heterogeneous Nuclear Ribonucleoprotein-K (HnRNP-K) on Urinary Bladder Carcinogenesis

Document Type: Research Articles

Authors

1 Pathology Departments,Theodor Bilharz Research Institute, Cairo, Egypt.

2 Urology Departments, Theodor Bilharz Research Institute, Cairo, Egypt.

Abstract

Objective: This study aimed to investigate the expression of cyclin D1 and hnRNP-K in relation to the pathological
findings in bladder cancer including the type, grade, muscle invasion and bilharzial association. Methods: We studied
the immunoexpression; as regard the percentage, intensity and score of both cyclin D1 and hnRNP-K in different bladder
lesions including 10 cases of cystitis; 10 cases of carcinoma insitu (CIS), 20 cases of Squamous cell carcinoma (SCC)
and 66 cases of urothelial carcinoma (UC). Results: High expression of cyclin D1 was found in UC compared to other
groups (p<0.001) and in UC with low grade, non-muscle invasive and papillary tumors compared to their counterparts
(p<0.05, hnRNP-K expression was found in SCC compared to other groups (p <0.001) and in UC with high grade, muscle invasive
and non-papillary tumors compared to their counterparts (p<0.001each). Bilharzial-associated UC showed higher
expression of hnRNP-K percent (p<0.05) compared to non-bilharzial cases. Conclusion: This study elucidated a possible
contribution of cyclin D1 and hnRNP-K expression in the initiation and progression of urinary bladder carcinoma,
so, both of them can be used in predicting progression of urinary bladder carcinoma and to differentiate between UC
and SCC in high grade tumors. The possible role of both markers in immunotherapy deserves supplementary studies.

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