Genetic Polymorphism of the Glutathione S-transferase Pi 1 (GSTP1) and Susceptibility to Cervical Cancer in Human Papilloma Virus Infected Northeastern Thai Women

Document Type: Research Articles

Authors

1 Department of Physiology, Khon Kaen University, Khon Kaen, Thailand.

2 HPV and EBV Carcinogenesis Research Group, Khon Kaen University, Khon Kaen, Thailand.

3 Chulabhorn International College of Medicine, Thammasat University,, Thailand.

4 Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, 1130033, Japan.

Abstract

Objective: We aimed to investigate any association between a genetic polymorphism of the detoxification GSTP1
gene and risk of cervical cancer in northeastern Thailand. Materials and Methods: Genotyping of GSTP1 was performed
for 198 squamous cell cervical cancer (SCCA) patients and 198 age-matched healthy controls with the PCR-RFLP
method. Results: The respective frequencies of the G allele were 0.33 and 0.26 in the controls and cases, the difference
being significant (OR = 0.69 [95% CI: 0.50-0.95, p=0.0192]). Among women infected with high-risk types of HPV, being
a heterozygous carrier was associated with a reduced risk of cervical cancer (adjusted OR = 0.32 [95% CI: 0.12-0.91,
p=0.031]). Similarly, a decreased risk was observed in heterozygous women with a non-smoking partner (adjusted OR
= 0.27 [95% CI: 0.09-0.83, p=0.023]). Conclusions: GSTP1 polymorphism could influence susceptibility to cervical
cancer among northeast Thai women; either as a independent factor or in combination with high-risk HPV infection.
Dual-testing of HPV and the GSTP1 might prove an effective screening tool for cervical cancer.

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