Document Type : Research Articles
Department of Physiology, Khon Kaen University, Khon Kaen, Thailand.
HPV and EBV Carcinogenesis Research Group, Khon Kaen University, Khon Kaen, Thailand.
Chulabhorn International College of Medicine, Thammasat University,, Thailand.
Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, 1130033, Japan.
Objective: We aimed to investigate any association between a genetic polymorphism of the detoxification GSTP1
gene and risk of cervical cancer in northeastern Thailand. Materials and Methods: Genotyping of GSTP1 was performed
for 198 squamous cell cervical cancer (SCCA) patients and 198 age-matched healthy controls with the PCR-RFLP
method. Results: The respective frequencies of the G allele were 0.33 and 0.26 in the controls and cases, the difference
being significant (OR = 0.69 [95% CI: 0.50-0.95, p=0.0192]). Among women infected with high-risk types of HPV, being
a heterozygous carrier was associated with a reduced risk of cervical cancer (adjusted OR = 0.32 [95% CI: 0.12-0.91,
p=0.031]). Similarly, a decreased risk was observed in heterozygous women with a non-smoking partner (adjusted OR
= 0.27 [95% CI: 0.09-0.83, p=0.023]). Conclusions: GSTP1 polymorphism could influence susceptibility to cervical
cancer among northeast Thai women; either as a independent factor or in combination with high-risk HPV infection.
Dual-testing of HPV and the GSTP1 might prove an effective screening tool for cervical cancer.