Mean Platelet Volume and Platelet Distribution Width Are Associated with Gallbladder Cancer

Document Type: Research Articles

Authors

1 Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang, China.

2 Department of Geriatrics, the Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang,China.

3 Departments of Internal Medicine and Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

4 Division of Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.

Abstract

Gallbladder cancer (GBC) represents the most common biliary tract malignancy. Activated platelets play an essential
role in cancer development and progression. Mean platelet volume (MPV) and platelet distribution width (PDW) are
commonly used indexes of activated platelets in clinical practice. The aim of the current study was to investigate the
association of MPV and PDW with GBC. 104 GBC patients and 109 normal control subjects were entered in this
study between January 2015 and December 2015. We collected all participants’ clinical and laboratory characteristics
at initial diagnosis. The odds ratios (ORs) for GBC were calculated using multivariate logistic regression analysis after
adjusting for confounding variables across MPV and PDW quartiles. MPV levels were markedly lower and PDW levels
were remarkably higher in GBC patients than control subjects. A significant correlation between PDW and lymph node
metastasis was detected. In addition, after adjusting for other risk factors, the ORs (95% CIs) for GBC in each MPV
quartile were 5.117 (1.939-13.506), 2.444 (0.917-6.516), 3.718 (1.381-10.007), and 1.000, respectively. The ORs (95%
CIs) for GBC in each PDW quartile were 1.000, 2.063 (0.825-5.162), 3.070 (1.108-8.507), and 12.108 (4.243-34.553),
respectively. In conclusion, decreased MPV and elevated PDW were independently associated with GBC. Our findings
suggest that MPV and PDW are available parameters for early detection of GBC.

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Main Subjects