Nasopharyngeal Carcinoma Protein Interaction Mapping Analysis via Proteomic Approaches

Document Type: Research Articles

Authors

1 Hearing Disorders Research Center and Department of Biology and Anatomical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

2 Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.

3 Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

4 Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

Nasopharyngeal carcinoma (NPC), although not very common in many parts of the world, is a major concern in
some countries, including Iran. Molecular studies are very helpful to provide essential information regarding underlying
carcinogenetic mechanisms. Here, considering NPC proteomic approaches, established biomarkers were designated for
protein-protein interaction network construction and analysis with corresponding plug-ins. A network of reported protein
markers was constructed and topological and biological process features were investigated. Centrality analysis showed
that JUN, CALM1, HSB1, and SOD1 are more important than other differentially expressed proteins in an interacting
pattern. What is more, by extending the network, Tp53, PRDM10, AKT1, ALB, HSP90AA1, and EGFR achieved the
highest values for NPC network strength. It can be concluded that these proteins as well as their contributing processes,
particularly in a second network, may be important for NPC onset and development. Targeting these candidate proteins
may allow novel treatment approaches following appropriate validation.

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