• Home
  • Browse
    • Current Issue
    • By Issue
    • By Author
    • By Subject
    • Author Index
    • Keyword Index
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Editorial Staff
    • Publication Ethics
    • Indexing and Abstracting
    • Related Links
    • FAQ
    • Peer Review Process
    • News
  • Guide for Authors
  • Submit Manuscript
  • Reviewers
  • Contact Us
 
  • Login
  • Register
Home Articles List Article Information
  • Save Records
  • |
  • Printable Version
  • |
  • Recommend
  • |
  • How to cite Export to
    RIS EndNote BibTeX APA MLA Harvard Vancouver
  • |
  • Share Share
    CiteULike Mendeley Facebook Google LinkedIn Twitter Telegram
Asian Pacific Journal of Cancer Prevention
Articles in Press
Current Issue
Journal Archive
Volume Volume 19 (2018)
Issue S1
Issue Issue 4
Issue Issue 3
Issue Issue 2
Issue Issue 1
Volume Volume 18 (2017)
Volume Volume 17 (2016)
Volume Volume 16 (2015)
Volume Volume 15 (2014)
Volume Volume 14 (2013)
Volume Volume 13 (2012)
Volume Volume 12 (2011)
Volume Volume 11 (2010)
Volume Volume 10 (2009)
Volume Volume 9 (2008)
Volume Volume 8 (2007)
Volume Volume 7 (2006)
Volume Volume 6 (2005)
Volume Volume 5 (2004)
Volume Volume 4 (2003)
Volume Volume 3 (2002)
Volume Volume 2 (2001)
Volume Volume 1 (2000)
Rasooli, S., Zarghami, N. (2018). Synergistic Growth Inhibitory Effects of Chrysin and Metformin Combination on Breast Cancer Cells through hTERT and Cyclin D1 Suppression. Asian Pacific Journal of Cancer Prevention, 19(4), 977-982. doi: 10.22034/APJCP.2018.19.4.977
Sara Rasooli; Nosratollah Zarghami. "Synergistic Growth Inhibitory Effects of Chrysin and Metformin Combination on Breast Cancer Cells through hTERT and Cyclin D1 Suppression". Asian Pacific Journal of Cancer Prevention, 19, 4, 2018, 977-982. doi: 10.22034/APJCP.2018.19.4.977
Rasooli, S., Zarghami, N. (2018). 'Synergistic Growth Inhibitory Effects of Chrysin and Metformin Combination on Breast Cancer Cells through hTERT and Cyclin D1 Suppression', Asian Pacific Journal of Cancer Prevention, 19(4), pp. 977-982. doi: 10.22034/APJCP.2018.19.4.977
Rasooli, S., Zarghami, N. Synergistic Growth Inhibitory Effects of Chrysin and Metformin Combination on Breast Cancer Cells through hTERT and Cyclin D1 Suppression. Asian Pacific Journal of Cancer Prevention, 2018; 19(4): 977-982. doi: 10.22034/APJCP.2018.19.4.977

Synergistic Growth Inhibitory Effects of Chrysin and Metformin Combination on Breast Cancer Cells through hTERT and Cyclin D1 Suppression

Article 17, Volume 19, Issue 4, April 2018, Page 977-982  XML PDF (434 K)
Document Type: Research Articles
DOI: 10.22034/APJCP.2018.19.4.977
Authors
Sara Rasooli1; Nosratollah Zarghami 2
1Department of Genetics, Faculty of Sciences, Islamic Azad University, Tabriz Branch, Tabriz, Iran.
2Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Receive Date: 15 October 2017,  Revise Date: 14 January 2018,  Accept Date: 17 February 2018 
Abstract
Objective: To explore the possibility of a novel chemopreventive strategy for improving breast cancer treatment,
the anticancer effects of a combination two natural compounds, Chrysin and Metformin, against T47D breast cancer
cells were investigated. Materials and Methods: After treatment of T47D cells with Metformin, Chrysin and the two
drugs in combination, toxicity to cancer cells was evaluated by MTT assay. Real time PCR was then used to determine
the expression levels of hTERT and cyclin D1 genes. Results: The MTT test findings showed that the combination of
metformin and chrysin had high synergistic effects in killing cancer cells. In addition PCR demonstrated a significant
decrease in cyclin D1 and hTERT gene expression in the T47D breast cancer cell line. Conclusion: The conmbination
of metformin and chrysin suppressing hTERT and cyclin D1 gene expression might offer an appropriate approach for
breast cancer therapy.
Keywords
breast cancer; Cyclin D1; hTERT; Metformin; Silibinin
Main Subjects
Cancer biology
Statistics
Article View: 45
PDF Download: 10
Home | Glossary | News | Aims and Scope | Sitemap
Top Top

 



 

Journal Management System. Designed by sinaweb.