Serum CXCL12, but not CXCR4, Is Associated with Head and Neck Squamous Cell Carcinomas

Document Type: Research Articles

Authors

1 Oral and Dental Disease Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

2 Student Research Committee, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.

3 Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran.

4 Department of Otolaryngology, Khalili Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.

Abstract

Background: Squamous cell carcinoma (SCC) is the most frequent malignancy of the head and neck (HN) region.
We here evaluated associations of stromal cell derived factor-1 (SDF-1or CXCL12) and its receptor, CXCR4, with
HNSCCs. Materials and Methods: Sixty newly diagnosed HNSCC patients were enrolled in the patient group, and 28
healthy individuals in the control group. Plasma levels of CXCL12 and CXCR4 were measured using ELISA kits.
Results: There was a significant difference in mean CXCL12, but not CXCR4, plasma levels between the patient and
control groups (P=0.0001). No significant associations were found between mean plasma levels of either CXCL12 or
CXCR4 with age, gender, tumor site, tumor size, lymph-node involvement or tumor stage. Conclusion: For the first
time, our findings demonstrate a significant association between serum CXCL12 but not CXCR4 levels and HNSCCs.

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