HPV Could be a Potential Factor of Survival in Laryngeal Cancer: a Preliminary Study in Mexican Patients

Document Type: Research Articles

Authors

1 Centro de Investigación en Dinamica Celular, Universidad Autonoma del Estado de Morelos, Cuernavaca ,Mexico.

2 Unidad de Investigación Médica en Enfermedades Oncológicas, Hospital de Oncología,Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico.

3 Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de Mexico, Mexico.

4 Servicio de Cabeza y Cuello, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico.

5 Departamento de Patología, Hospital de Oncología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico.

Abstract

Introduction: In Head and Neck (HN) cancer, the High-Risk Human Papillomavirus (hr HPV) infection has been
associated in about 40% of these tumors. The hr HPV infection is one of the etiological factors of several epithelial
tumors; however, its association with the prognosis has not yet been established for patients with Laryngeal Squamous
Cell Carcinoma (LSCC). On the other hand, Epidermal Growth Factor Receptor (EGFR) is a molecular marker widely
studied in cancer and its overexpression has been associated with poor prognosis in some types of cancer, including
the HN cancer. In the present study, we analyzed EGFR expression and HPV detection in a cohort of Mexican patients
with LSCC and define their association with clinical-pathological and survival parameters. Methods: EGFR expression
analysis was performed by immunohistochemistry assay. A tissue array was constructed based on 30 paraffin-embedded
tissue samples. HPV detection was performed by PCR. The results were then compared with the clinical-pathological
variables and outcome measures (Kaplan Meier and Cox analysis). Results: High expression of EGFR was observed
in 43% of the samples and 20% of HPV detection. The statistical analyses provided evidence of disassociation between
clinical-pathological parameters and EGFR expression, but there was an association with poor prognosis. Interestingly,
HPV detection is slightly associated with good prognosis. Conclusion: Both, EGFR overexpression and HPV presence
could be associated with an unfavorable prognosis in patients with LSCC, independently of other clinical-pathological
factors.

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