Association of IL-10 rs1800871 and rs1800872 Polymorphisms with Breast Cancer Risk: A Systematic Review and Meta-Analysis

Document Type: Systematic Review and Meta-analysis

Authors

1 Department of Pathology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

2 Department of Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

3 Department of Gynecology and Obstetrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

4 Department of Biology, Ashkezar Branch, Islamic Azad University, Yazd, Iran.

5 Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Abstract

Background: The rs1800871 and rs1800872 polymorphisms of interleukin 10 (IL-10) gene has been indicated to
be associated with breast cancer (BC) risk, but study results are still debatable. To derive a more precise evaluation, we
performed a comprehensive meta-analysis. Methods: Multiple electronic databases were searched to identify studies
assessing the IL-10 rs1800871 and rs1800872 polymorphisms with BC risk. Results: A total of 21 case-control studies
with 6054 cases and 6355 controls were included in this met-analysis. There was a significant association between the
rs1800871 polymorphism and BC risk (CT vs. TT: OR= 1.17, 95% CI 1.01-1.35, p=0.02; and CC+CT vs. TT: OR= 1.29,
95% CI 1.00-1.66, p=0.04). Moreover, increased BC risks were also associated with the rs1800872 polymorphism (C
vs. A: OR= 1.29, 95% CI 1.04-1.60, p=0.01; CC vs. AA: OR= 1.54, 95% CI 1.03-2.30, p=0.03; CC+CA vs. AA: OR=
1.43, 95% CI 1.01-2.01, p=0.03; and CC vs. CA+AA: OR= 1.23, 95% CI 1.01-1.51, p=0.04). A pooling of the studies
was also conducted by ethnicity, but failed to show an association of IL-10 rs1800871 and rs1800872 polymorphism
with BC risk in Asians and Caucasians. Conclusions: Our results are inconsistent with previous meta-analysis suggests
that IL-10 rs1800871 and rs1800872 polymorphisms might contribute to BC susceptibility in overall population, but
not by ethnicity.

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