Document Type: Systematic Review and Meta-analysis
Department of Pathology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Gynecology and Obstetrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Biology, Ashkezar Branch, Islamic Azad University, Yazd, Iran.
Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Background: The rs1800871 and rs1800872 polymorphisms of interleukin 10 (IL-10) gene has been indicated to
be associated with breast cancer (BC) risk, but study results are still debatable. To derive a more precise evaluation, we
performed a comprehensive meta-analysis. Methods: Multiple electronic databases were searched to identify studies
assessing the IL-10 rs1800871 and rs1800872 polymorphisms with BC risk. Results: A total of 21 case-control studies
with 6054 cases and 6355 controls were included in this met-analysis. There was a significant association between the
rs1800871 polymorphism and BC risk (CT vs. TT: OR= 1.17, 95% CI 1.01-1.35, p=0.02; and CC+CT vs. TT: OR= 1.29,
95% CI 1.00-1.66, p=0.04). Moreover, increased BC risks were also associated with the rs1800872 polymorphism (C
vs. A: OR= 1.29, 95% CI 1.04-1.60, p=0.01; CC vs. AA: OR= 1.54, 95% CI 1.03-2.30, p=0.03; CC+CA vs. AA: OR=
1.43, 95% CI 1.01-2.01, p=0.03; and CC vs. CA+AA: OR= 1.23, 95% CI 1.01-1.51, p=0.04). A pooling of the studies
was also conducted by ethnicity, but failed to show an association of IL-10 rs1800871 and rs1800872 polymorphism
with BC risk in Asians and Caucasians. Conclusions: Our results are inconsistent with previous meta-analysis suggests
that IL-10 rs1800871 and rs1800872 polymorphisms might contribute to BC susceptibility in overall population, but
not by ethnicity.