Document Type: Research Articles
Department of Dermatology-Venereology, Faculty of Medicine, Udayana University-Sanglah General Hospital, Bali, Indonesia.
Pre Graduate in Dermatology and Venereology Medicine, Faculty of Medicine, Udayana University-Sanglah General Hospital, Bali, Indonesia.
Background: Condyloma acuminata is a type of human papilloma virus (HPV) infection in the anogenital area
and often associated with immunosuppressive conditions, such as human immunodeficiency virus (HIV). Low plasma
zinc levels could cause alteration of cellular immunity, leading to reduction of interleukin-2 (IL-2) and interferon-γ
(IFN-γ), cytokines required for inhibition of HPV replication. Moreover, low plasma zinc levels could cause disruption
of apoptotic regulation, results in the unimpeded proliferation of epithelial cells infected with HPV. This study aimed to
compare the mean plasma zinc levels in condyloma acuminata patients with HIV and without HIV infection. Methods:
This study used a cross-sectional method, involving 27 condyloma acuminata patients without HIV infection and 18
patients with HIV infection, who agreed to enroll and signed the informed consent. This study was conducted in the
dermatology and venereology outpatient clinic in Sanglah Hospital and Kerti Praja Foundation, Denpasar. Bivariate
analysis of the characteristics, age, sex orientation, location of lesion, clinical form of lesion, type of cases, duration
of condyloma acuminata, age of the first sexual contact, comorbidity, treatment history, and mean plasma zinc level
of condyloma acuminata patients with HIV and without HIV infection. The CD4+ cell count and history of ARV
treatment were also obtained form patients with HIV infection. Results: A total of 45 subjects were diagnosed with
condyloma acuminata, consisted of 27 subjects with condyloma acuminata without HIV infection and 18 subjects with
HIV infection, showing average age of 32.04 ± 10.414. Mean plasma zinc levels in condyloma acuminata patients
with HIV infection was significantly lower than subjects without HIV infection, and the difference in mean plasma
zinc levels was 7.31 μg/dL (95% CI 2.25 - 12.37, p <0.05). Conclusions: The mean plasma zinc levels in condyloma
acuminata patients with HIV was significantly lower than those of without HIV infection.