The Possible Role of Interleukin (IL)-18 and Nitrous Oxide and Their Relation to Oxidative Stress in the Development and Progression of Breast Cancer

Document Type: Research Articles


1 Department of Chemical Pathology, Medical Research Institute, Alexandria University, Alexandria, Egypt.

2 Department of Cancer Management and Research, Medical Research Institute, Alexandria University, Alexandria, Egypt.

3 Department of Surgery, Medical Research Institute, Alexandria University, Alexandria, Egypt.


Background: Cancer breast is the most common malignant tumor in females globally. Mechanisms linking
inflammatory cytokines and tumour growth and progression have not been established. Interleukin (IL)-18 has a
modifying role in the immune defense against tumor cells. It induces production of IFN-γ. It also increases the immune
cells cytotoxic activity and enhances the production of other proinflammatory cytokine. Nitric oxide (NO) has both
promoting and inhibiting effects on tumorigenesis. Oxidative stress is a phenomenon that leads to oxidative damage
of biomolecules, mutagenesis and carcinogenesis. Objective: The purpose of this research is to identify the potential
role of IL18 and NO and their relation to oxidative stress in the development of cancer breast. Patients and Methods:
This study included 120 women split into two groups ; control group and patient groups that divided into: group B (30
patients with benign breast tumors), group N (30newly diagnosed cancer breast patients) ; and group M (30 metastatic
cancer breast patients). Results: Serum total anti-oxidant capacity was significant high in both cancer breast groups.
Total oxidative capacity was significantly higher level in metastatic group. NO levels were significantly higher values
in the three cancer breast patients groups compared to control group.IL18 was significantly high in the metastatic
group. Conclusions: Serum IL-18 and NO activity can be used as a marker for evaluating disease activity in patients
with cancer breast.


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