Document Type : Research Articles
Department of Chemistry, College of Education for Pure Sciences, University of Basrah, Basrah, Iraq.
Ministry of Education, General Directorate of Education in Basrah, Basrah, Iraq.
Department of Applied Chemistry, College of Applied Sciences, University of Samarra, Iraq.
Background: Wild edible plants are good sources for bioactive compounds, vitamins, and minerals with various applications. They can play a role in supporting the immune system and are highly beneficial as resources. Suaeda monoica Forssk is a wild edible plant that grows in Iraq and it’s biological activities have not yet reported. Methods: Saueda monoica Forssk bioactive compounds were extracted by a microwave-assisted extraction method using ethanol as a solvent, and its chemical composition was analyzed by GC-MS. The biological activities were evaluated via antioxidant, anti-liver-cancer, antibacterial, and toxicity tests in vitro. Results: The results of GC-MS analysis showed that there were about 20 bioactive compounds. The most abundant compound was N,N-Dimethylglycine methyl ester, followed by 9,12,15-Octadecatrienoic acid, n-Hexadecanoic acid, and N,N-Dimethylglycine. The antioxidant activity of the ethanol extract of the plant showed a significant IC50. The extract of S. monoica against liver cancer cells (HCAM) showed significant toxicity. Flow cytometric analysis showed a significant induced apoptosis and cell cycle arrested at G1 phase. Conclusions: The results indicated the significance of the components of Iraqi S. monoica Forssk by MAE method as a potential food supplement in nutrition systems to prevent liver cancer and enhance the liver’s defense against diseases.