CD133 Role in Oral Carcinogenesis

Document Type : Research Articles


1 Department of Dental Clinic, Division of Oral Pathology, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Fortaleza, Brazil.

2 Department of Dental Clinic, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Fortaleza, Brazil.

3 Department of Oral Pathology, Faculty of Dentistry, Universidade de Fortaleza, Fortaleza, Ceara, Brazil.

4 School of Dentistry, Federal University of Ceará Campus Sobral, Sobral, Brazil.

5 Departament of Morphology, School of Medicine, Federal University of Ceará, Fortaleza, Brazil.


Objective: to investigate CD133 immunoexpression, cancer stem cells marker, in oral epithelial dysplasias (OEDs) and oral squamous cells carcinomas (OSCCs) and understandits possible involvement in the malignant transformation process of these lesions and to better elucidate their biological behavior. Material and methods: Tissue samples of 15 cases of OSCCs and 15 OEDs were subjected to CD133 antibody immunohistochemistry reactions. The analysis used quantitative parameters (number of immunostained cells regardless of immunostaining sublocations). Results: All samples of OSCCs and OEDs showed positive immunostaining, with no significant difference between these groups (p = 0.283). We did not observe statistical difference between the degree of dysplasia and the amount of CD133+ cells (p = 0.899). CD133 immunoexpression showed no association with the OEDs and OSCCs sites. It was observed that nuclear and cytoplasmic immunostaining was more evident with the progression of the malignant process. Conclusion: It is suggested that the CD133 cellular localization together with the histopathological criteria of OEDs classification can contribute to provide more concrete indications about the oral carcinogenesis process.


Main Subjects

Volume 21, Issue 9
September 2020
Pages 2501-2506
  • Receive Date: 26 March 2019
  • Revise Date: 07 July 2020
  • Accept Date: 10 September 2020
  • First Publish Date: 10 September 2020