Document Type : Research Articles
Department of Anatomical Pathology, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia.
Department of Histology, Faculty of Medicine, Universitas Muslim Indonesia, Makassar, Indonesia.
Department of Public Health, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia.
Department of Anatomical Pathology, Faculty of Medicine, Universitas Muhammadiyah Makassar, Makassar, Indonesia.
Department of Anatomical Pathology, Faculty of Medicine, Universitas Muslim Indonesia, Makassar, Indonesia.
Objective: To analyze the role of cancer stem cells (CSC) in ovarian carcinogenesis through the identification of CD133 expression in the normal ovary (NO), serous cystadenoma (SC), borderline serous tumour (BST), low-grade serous carcinoma (LGSC), and high-grade serous carcinoma (HGSC). Materials and methods: A total of 48 tissue samples contain 5 NO, 10 SC, 5 BST, 8 LGSC, and 20 HGSC were stained with anti-CD133 antibody by immunohistochemical protocol. The difference in the H-score of CD133 expression between groups and their relationship to age, histomorphology, and localization was analyzed. Results: CD133 expression varied among tumor groups, with clinicopathologic parameters showing diverse associations (age p = 0.773; histomorphology p = 0.001; and localization p = 0.026). The comparison of CD133 H-scores differed significantly between each group (p = 0.0031), in which precursor and malignant lesions possessed more robust CD133 expression. Conclusion: The presence of CD133 cellular expression and localization in different types of serous ovarian tumours suggests that these markers are involved in ovarian tumorigenesis.