Anti-proliferative, Anti-angiogenic and Anti-inflammatory Effects of Moringa peregrina Leaf Extracts on Testosterone- Induced Benign Prostatic Hyperplasia in Rats

Document Type : Research Articles


1 Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid-21163, Jordan.

2 Department of Biological Sciences, Faculty of Science, Yarmouk University, Irbid-21163, Jordan.

3 Department of Biology, Jerash University, Jerash, Jordan.

4 Department of Chemistry, Faculty of Science, Yarmouk University, Irbid-21163, Jordan.

5 School of Pharmacy and Pharmaceutical Sciences, Ulster University, Coleraine BT521SA,UK.

6 Vital Care Medical Center, Men’s Health Center Limerick, Irelandv.

7 Department of Pharmacy, Independent University, Dhaka-1229, Bangladesh.

8 Department of Pharmacy and Pharmaceutical Sciences, Huddersfield University, UK.


Aim: To investigate the potential anti-inflammatory and biochemical effects of Moringa peregrina leaf extracts on testosterone-induced benign prostatic hyperplasia (BPH) in rats. Methods: Six groups of rats (each group included 5 rats) were included in this study. The groups included: 1) the control group, 2) the testosterone-induced BPH group, 3) with 50 mg/kg bwt (bodyweight) oil-treated BPH, 4) with 100 mg/kg bwt. oil-treated BPH, 5) with 500mg/kg bwt. ethanol treated BPH and 6) with 1,000 mg/kg bwt. aqueous treated BPH group. Biochemical markers were measured to evaluate the effect of M. peregrina leaf extracts. Results: Our results showed a significant improvement in the thickness of epithelial cells of the BPH glandular tissues when treated with different M. peregrina extracts (p < 0.05). In addition, M. peregrina extracts showed anti-inflammatory, anti-proliferative and anti-angiogenesis effects on the BPH tissues by reduction of IL-6, PCNA and VEGF-A, respectively. Conclusion: Our preclinical study concluded that M. peregrina leaf extracts showed a significant effect on BPH by reducing inflammation, proliferation, and angiogenic processes with no signs of toxicity.


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