Histomorphology and Immunohistochemistry of Gastrointestinal Stromal Tumors in a Malaysian Population

Document Type : Systematic Review and Meta-analysis


1 Pathology, Medicine, International Medical University, Bukit Jalil, Malaysia

2 Pathology, Medicine, International Medical University,Bukit Jalil, Malaysia.

3 Pathology, Medicine, International Medical University, Kuala Lumpur, Malaysia.

4 Department of Pathology, Hospital Tuanku Ja’afar, Seremban, Malaysia.

5 Department of Surgery, Hospital Tuanku Ja’afar, Seremban, Malaysia.


Purpose: To study histomorphological and immunohistochemical patterns of gastro-intestinal stromal tumours (GISTs) in Malaysia.
Materials and Methods: A total of 29 GIST cases from Hospital Tuanku Ja’afar, Seremban ,were studied retrospectively over a period of 10 years from January 2002 to December 2011. Patient demographic data like age, sex and etnicity were collected. Tumour characteristics like site, maximum dimension and specimen type were analysed. Evaluation was according to established criteria into very low, low, intermediate and high-risk categories. Immunohistochemical characteristics were also analysed.
Results: The mean age of patients was 59.7 years. Males (59%) were found to be more commonly affected than females (41%). The Chinese (45%) were commonly affected than Malays (41%), and Indians (10%). The most common symptom was pain in the abdomen (13.8%). More than half of the cases were seen in stomach (53%). The tumour size ranged from 1.5 cm to 17 cm with a mean of 6.94cm. Microscopic findings revealed that the spindle cell type was the most common (76%). It was observed that the majority of the cases (48%) were categorised in the intermediate risk group. Immunohistochemical staining showed positivity for CD117 (78.6%), CD34 (71.4%), vimentin (86.2%), S-100 (27.6%), SMA (35.7%), PKC THETA (46.4%) and PDGRFA (67.9%).