The present investigation was undertaken to explore the anti-tumor promoting activity of Rosemarinus officinalison two-stage skin carcinogenesis, induced by a single topical application of 7, 12-dimethylbenz(a)anthracene andpromoted by treatment of croton oil for 15 weeks in Swiss albino mice. Oral administration of Rosemary leaf extractat a dose of 1000 mg/ kg b. wt. / day at pre, peri and post-initiational phases, was found to be effective in decreasingthe tumor incidence (50, 41.7, 58.3%, respectively) in comparison to the control (100%). Furthermore, the cumulativenumber of papillomas, tumor yield and tumor burden were also found to be reduced in R. officinalis-treated animals.This was associated with significant alteration in liver lipid peroxidation and glutathione (GSH) levels.
(2006). Modulatory Influence of Rosemarinus officinalis on DMBA-induced Mouse Skin Tumorigenesis. Asian Pacific Journal of Cancer Prevention, 7(2), 331-335.
MLA
. "Modulatory Influence of Rosemarinus officinalis on DMBA-induced Mouse Skin Tumorigenesis". Asian Pacific Journal of Cancer Prevention, 7, 2, 2006, 331-335.
HARVARD
(2006). 'Modulatory Influence of Rosemarinus officinalis on DMBA-induced Mouse Skin Tumorigenesis', Asian Pacific Journal of Cancer Prevention, 7(2), pp. 331-335.
VANCOUVER
Modulatory Influence of Rosemarinus officinalis on DMBA-induced Mouse Skin Tumorigenesis. Asian Pacific Journal of Cancer Prevention, 2006; 7(2): 331-335.
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