The aim of this retrospective study was to clarify the clinopathologic profile of endometrial cancers in womenaged 45 years or younger. All patients with histopathologically confirmed endometrial cancer treated atSongklanagarind Hospital from 1996-2005 were included. Of the 51 identified, 40 (78.4%) were in stage I, 7(13.7%) in stage II, and 4 (7.8%) in stage III. The age range was 25-45 years (median 41) with a body mass indexranging from 17.6-44.2 (median 27.2). Eighty one percent reported abnormal vaginal bleeding, and twenty fourpercent polycystic ovaries. Prevalences of diabetes mellitus, hypertension and thyroid disease were 17.7%, 15.7%,and 3.9%, respectively. Seven cases (13.7%) had synchronous ovarian cancer with endometriod adenocarcinomaas the most common histopathological form. Forty patients had well differentiated, 8 moderately differentiatedand 2 poorly differentiated tumors. The 5-year disease-free survival (and 95% CI) and 5-year overall survivalrates were 88.0% (75.1-94.4%) and 87.5% (74.1-94.2%), respectively. Univariate analysis revealed that patientswho had a history of hypertension or lymph node metastasis had a poor prognosis. We conclude that the majorityof women aged 45 years or younger with endometrial cancer were obese and the tumors were most commonly inan early stage and were well differentiated.
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