Clinicopathologic Variables and Survival Comparison of Patients with Synchronous Endometrial and Ovarian Cancers versus Primary Endometrial Cancer with Ovarian Metastasis

Objectives: To determine the clinicopathologic variables and survival in the patients with synchronousendometrial and ovarian cancer (synchronous group) compared to the patients with primary endometrial cancerwith ovarian metastasis (metastatic group).
Methods: The medical records of 423 endometrial cancer patientswho received primary surgery were reviewed. Fourteen patients were diagnosed as synchronous group while 49patients were diagnosed as metastatic group.
Results: The median age in synchronous group was significantlyyounger than metastatic group (47 versus 56 years). More nulliparous and premenopausal patients weredemonstrated in synchronous group. Synchronous group had significantly higher incidence of low grade tumorand lower incidence of deep myometrial invasion. All patients in synchronous group presented in stage Iendometrial cancer. Moreover, most patients (85.7%) presented in early stage ovarian cancer and only 14.3% inadvanced stage ovarian cancer. Synchronous group had better disease free survival (DFS) and overall survival(OS) than metastatic group. Estimated 5 years DFS was 64.2% versus 41.5%, (P = 0.17) and 5 years OS was92.8% versus 48.5% (P = 0.036).
Conclusion: The patients in synchronous group were younger, more nulliparousand better prognosis than the patients in metastatic group.