According to cancer stem cell hypothesis, cancer stem cells with unlimited self-renewal and multidifferentiationproperties such as adult stem cells are the root cause of cancer initiation and progression, andtargeted therapy to cancer stem cells is to become the most efficient therapy of cancer. However, specific markersshould be discovered to define cancer stem cells accurately before targeted therapy. Therefore, we propose amodel of specific markers of cancer stem cells and how to search these markers.
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