In this study we investigated in vitro and in vivo xenograft growth inhibition by crocin isolated from Kashmirisaffron (Crocus sativus). It was found that crocin decreased cell viability in DLA cells, in a concentration- andtime-dependent manner. Significant increase in the lifespan of Dalton’s lymphoma bearing animals was notedby 37% and 44%, respectively. Furthermore, animals given treatment before induction of cancer showed 58%increase in lifespan and there was 95.6% reduction of solid tumor in crocin treated animals on the 31st day aftertumor inoculation. Crocin also showed significant impact on hematological parameters, like the hemoglobincount and numbers of lymphocytes. These findings support the conclusion that crocin from Crocus sativus hassignificant anti-tumor activity.
(2009). Crocin from Kashmiri Saffron (Crocus sativus) Induces in Vitro and in Vivo Xenograft Growth Inhibition of Dalton ’ s Lymphoma (DLA) in Mice. Asian Pacific Journal of Cancer Prevention, 10(5), 887-890.
MLA
. "Crocin from Kashmiri Saffron (Crocus sativus) Induces in Vitro and in Vivo Xenograft Growth Inhibition of Dalton ’ s Lymphoma (DLA) in Mice". Asian Pacific Journal of Cancer Prevention, 10, 5, 2009, 887-890.
HARVARD
(2009). 'Crocin from Kashmiri Saffron (Crocus sativus) Induces in Vitro and in Vivo Xenograft Growth Inhibition of Dalton ’ s Lymphoma (DLA) in Mice', Asian Pacific Journal of Cancer Prevention, 10(5), pp. 887-890.
VANCOUVER
Crocin from Kashmiri Saffron (Crocus sativus) Induces in Vitro and in Vivo Xenograft Growth Inhibition of Dalton ’ s Lymphoma (DLA) in Mice. Asian Pacific Journal of Cancer Prevention, 2009; 10(5): 887-890.
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