Insulin-like Growth Factor (IGF)-I, IFG-II, IGF Binding Protein-3, and Risk of Colorectal Cancer: a Nested Case-control Study in the JACC Study


Insulin-like growth factor (IGF)-I and IGF-II are important mitogen and IGF binding protein-3 (IGFBP-3)exerts opposite effects. However, the results of epidemiological studies on cancer influence are somewhatcontroversial, and mainly from Western countries. In the present study, we therefore examined associations ofserum IGF-I, IGF-II and IGFBP-3 with colorectal cancer risk among participants in the JACC Study in Japan.After matching 3 controls to cases by sex, age, and study area, a total 101 risk sets were examined using aconditional logistic regression model adjusted for body mass index, smoking habit, alcohol consumption andfamily history of colorectal cancer. The odds ratios (and 95% CIs) for colorectal cancer mortality among thehighest tertiles of IGF-I, IGF-II, and IGFBP-3, compared to the lowest tertiles were 1.01 (0.49-2.10), 1.02 (0.55-1.91), and 1.22 (0.63-2.38), respectively. No linear trends were observed. The lack of any association was notaltered after additional adjustment for mutual markers of IGF-I/IGF-II or IGFBP-3, 0.76 (0.34–1.71) for IGFI,0.66 (0.30–1.45) for IGF-II, and 1.11 (0.47-2.66) for IGFBP-3. Our prospective data thus indicated that thereis no association of IGF-I, IGF-II, and IGFBP-3 with colorectal cancer risk in the Japanese population. Althoughthese markers might be etiologically significant in relation to colorectal cancer, we did not obtain evidencesupporting this hypothesis.


Volume 10, Supplement
December 2009 Serum Components and Lifestyle Factors / Risk of Cancer: Results from the JACC Study Guest Editors: Akiko Tamakoshi and Koji Suzuki
December 2009
Pages 45-49