Lack of Influence of DNA Repair Gene OGG1 Codon 326 Polymorphisms of Gastric Cancer Risk in the Kashmir Valley


Damage to DNA may lead to carcinogenesis but is repaired through activation of pathways involvingpolymorphic enzymes, including human 8-oxoguanine glycosylase 1 (OGG1). The present study aimed to assessthe role of genetic variants of DNA repair gene OGG1 Ser326Cys in susceptibility to gastric cancer in Kashmirvalley. A case control study was performed in 303 subjects (108 gastric cancer and 195 healthy controls), allgenotyped through the polymerase chain reaction (PCR). Data weres statistically analyzed using the chi-squaretest and the logistic regression model. The distribution of OGG1 genotypes among controls and gastric cancercases did not show any significant differences. Although smokers and high salted tea drinkers themselves wereat higher risk for gastric cancer (OR=8.975, P=0.0001; OR=14.778, P=0.0001), interaction with OGG1 Ser326Cysdid not further modulate the risk. In conclusion, our findings suggest that the OGG1 polymorphism does notinfluence either gastric cancer risk independently or by interaction with smoking or salted-tea consumption inthe Kashmir valley.