Anti-tumour, Anti-mutagenic and Chemomodulatory Potentialof Chlorophytum borivilianum

In the present investigation anti-tumour, anti-mutagenic and chemomodulatory potential of Chlorophytumborivilianum were evaluated. Chlorophytum borivilianum root extract had no toxic effect up to a dose of 800 mg/kg body weight/day. Significant increase (p<0.05 to p<0.001) in the activity of reduced glutathione (GSH), catalase(CAT) and superoxide dismutase (SOD) and a significant decrease in the hepatic MDA level were observed at100, 400, and 800 mg/kg body weight of Chlorophytum borivilianum root extract when compared with the controlvalue. Skin papillomagenesis studies demonstrated a significant (p<0.001) decrease in cumulative numbers ofpapilloma, tumour incidence, tumour burden, tumour size and tumour weight and significant (p<0.01) increasein average latent period when the animals received Chlorophytum borivilianum root extract at a dose level of 800mg/kg body weight/day orally in double distilled water at pre, peri and post initiation stages of carcinogenesis. Asignificant reduction in the frequency of chromosomal aberration and micronuclei was observed in the treatedanimals as compared to carcinogen controls. The present investigation suggests that Chlorophytum borivilianumhas anti-tumour, anti-mutagenic and chemomodulatory effects.