Endometrial Cancer in Thai Women: Clinico-pathological Presentation and Survival

Objective: To assess the characteristic features, treatment, survival, and prognostic factors of Thai endometrialcancer (EMC) patients.
Methods: Clinico-pathological data of EMC patients who were treated in the institutionfrom 1992 to 2008 were collected. Survival rates and prognostic factors were studied.
Results: The mean age ofthe 261 patients was 55.4 ± 9.92 years. The most common complaint was abnormal uterine bleeding (87.3%).More than half (75.4%) had other medical illnesses or other cancers (10.7%). The majority (78%) had earlystage disease. Post-operative adjuvant therapy was given in 41.4%; the most common was radiation therapy(37.2%). From a median follow-up of 57.5 months (range 0.03-212.3 months), progressive disease was encounteredin 16 patients. Eighteen experienced recurrence (three local, 13 distant metastases and two local and distant).Overall, 30 patients died of cancer, while 18 died of other medical illnesses. The 5-year progression-free, cancerspecific, and overall survivals (95% confidence intervals) were 86.5% (82.1-90.8%), 88.0% (83.9-92.2%), and83.6% (78.7-88.4%), respectively. Significant prognostic factors for survival were: histology, grade, depthof myometrial invasion, cervical involvement, lymphovascular invasion, lymph node status, and Her-2/ neuexpression.
Conclusion: Most endometrial cancer patients in Thailand present at early stages and experiencegood survival outcomes.