Helicobacter Pylori Infection Reduces the Risk of Esophageal Squamous Cell Carcinoma: A Case-Control Study in Iran


Background: Some studies have indicated a protective role of H.pylori against risk of esophageal squamouscell carcinoma (ESCC). The purpose of this study was to explore this possible relationship in a case-controlstudy.
Methods: One hundred consecutive patients diagnosed with ESCC and 100 healthy people were enteredwith informed consent. All were asked to provide a blood sample and serum immunoglobulin G (IgG) antibodiesagainst HP-CSAs were measured with an enzyme-linked immunosorbent assay (ELISA).
Results: There wassignificant reverse association between H. pylori positivity and tumour development (OR=0.28, 95% CI: 0.15-0.54), but not with a Cag A positive status.
Conclusion: Our findings provide further evidence that H. pyloriinfection decreases the risk of ESCC but that this is not linked to a Cag A positive status.